Evaluation of the safety of Sanyak (Dioscoreae rhizoma) pharmacopuncture according to the extraction method: a double-blind randomized controlled trial

The study was conducted to evaluate the safety of Sanyak (Dioscoreae rhizoma) pharmacopuncture by injecting to healthy participants. Among the subjective symptoms, pain after the injection was statistically significant in the group injected with alcohol extract of Sanyak. The mean platelet volume and blood in the urinalysis after the injections were statistically significant between groups. After injections, the total protein level in liver function tests and hematocrit changed significantly. However, all of these changes were within normal limits, and Sanyak pharmacopuncture did not cause any severe physical responses or subjective symptoms and may, therefore, be considered safe.