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Related Concept Videos

Distribution and Dispersion00:54

Distribution and Dispersion

To understand intra-specific interactions in populations, scientists measure the spatial arrangement of species individuals. This geographic arrangement is known as the species distribution or dispersion. Highly territorial species exhibit a uniform distribution pattern, in which individuals are spaced at relatively equal distances from one another. Species that are highly tied to particular resources, such as food or shelter, tend to concentrate around those resources, and thus exhibit a...
Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...

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Related Experiment Video

Updated: May 13, 2026

Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection
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Dissemination: bringing translational research to completion.

Florence Clark1, Daniel J Park, Janice P Burke

  • 1Division of Occupational Science and Occupational Therapy, School of Dentistry, University of Southern California, Los Angeles, CA 90089, USA. fclark@usc.edu

The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association
|February 26, 2013
PubMed
Summary
This summary is machine-generated.

Bridging the gap between health care research and practice requires strategic implementation plans. These plans ensure evidence-based interventions reach target populations for improved patient care.

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Area of Science:

  • Health Services Research
  • Implementation Science
  • Knowledge Translation

Background:

  • A persistent gap exists between innovative health care research findings and their application in real-world clinical settings.
  • The dissemination of A. Jean Ayres' sensory integration procedures serves as a case study for examining research-to-practice transitions.
  • The University of Southern California Well Elderly Studies research team faces current challenges in knowledge utilization.

Purpose of the Study:

  • To examine the transition from research to implementation in health care.
  • To discuss the development of effective implementation plans for translating evidence into practice.
  • To identify key components for successful dissemination of research-generated knowledge.

Main Methods:

  • Drawing upon principles from the emerging field of implementation science.
  • Analyzing the challenges faced by the University of Southern California Well Elderly Studies research team.
  • Outlining essential elements for a comprehensive implementation plan.

Main Results:

  • Implementation plans should strategically address intervention reach within target populations.
  • Plans must consider the applicability of interventions across various settings.
  • Identifying and engaging leaders and stakeholder groups is crucial for practitioner uptake.
  • Anticipating and mitigating challenges to dissemination is a key component of successful implementation.

Conclusions:

  • Developing a proactive implementation plan is essential for effective knowledge translation in health care.
  • Addressing reach, setting, leadership, stakeholders, and dissemination challenges increases the likelihood of successful intervention uptake.
  • Effective dissemination strategies enhance the translation of research into improved practice and consumer care.