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Updated: May 13, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
Treatment modification of yttrium-90 radioembolization based on quantitative positron emission tomography/CT imaging
Ted T Chang1, Austin C Bourgeois, Anastasia M Balius
1Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA.
Abstract:
Treatment activity for yttrium-90 ((90)Y) radioembolization when calculated by using the manufacturer-recommended technique is only partially patient-specific and may result in a subtumoricidal dose in some patients. The authors describe the use of quantitative (90)Y positron emission tomography/computed tomography as a tool to provide patient-specific optimization of treatment activity and evaluate this new method in a patient who previously received traditional (90)Y radioembolization. The modified treatment resulted in a 40-Gy increase in absorbed dose to tumor and complete resolution of disease in the treated area within 3 months.
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