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Related Experiment Video

Updated: May 13, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Carbapenems.

Dominique Breilh1, Jeannette Texier-Maugein, Bernard Allaouchiche

  • 1Laboratory of Clinical Pharmacokinetics and Clinical Pharmacy,INSERM U1034, Haut-Lévêque hospital, CHU Bordeaux, University of Bordeaux, Segalen, Pessac, France. dominique.breilh@chu-bordeaux.fr

Journal of Chemotherapy (Florence, Italy)
|February 26, 2013
PubMed
Summary

Carbapenems exhibit similar activity spectra, but optimal use, especially for critically ill patients, requires individualized dosing based on pharmacokinetic/pharmacodynamic (PK/PD) properties like T(>MIC) to maximize outcomes and minimize resistance.

Related Experiment Videos

Last Updated: May 13, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Area of Science:

  • Pharmacology
  • Microbiology
  • Infectious Diseases

Background:

  • Carbapenems are broad-spectrum beta-lactam antibiotics crucial for treating severe bacterial infections.
  • Understanding their comparative strengths, weaknesses, and optimal usage is vital for effective clinical application and antimicrobial stewardship.

Purpose of the Study:

  • To evaluate the microbiological, clinical, and pharmacokinetic/pharmacodynamic (PK/PD) properties of carbapenems.
  • To define optimal conditions for using new-generation carbapenems to enhance efficacy and combat resistance.

Main Methods:

  • A comprehensive literature review was conducted.

Main Results:

  • Carbapenem activity spectra are largely similar, except for ertapenem, with resistance linked to porin alterations and beta-lactamases.
  • Pharmacokinetic properties are similar, but T(>MIC) is a key predictor of efficacy; imipenem may require >66% T(>MIC) in specific patient groups.
  • Continuous or extended infusion of carbapenems shows comparable efficacy to intermittent infusion, particularly beneficial for critically ill patients.

Conclusions:

  • Individualized dosing guided by therapeutic drug monitoring is essential for maximizing clinical outcomes.
  • Minimizing antibiotic resistance necessitates a tailored approach to carbapenem therapy.