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The embryo freezing programme at Groote Schuur Hospital. First results.
K Wiswedel1, J McLoughlin, C North
1Department of Obstetrics and Gynaecology, Groote Schuur Hospital.
Summary
This study on in vitro fertilization (IVF) found that cryopreservation of surplus embryos using propanediol or glycerol resulted in a 25% pregnancy rate per transfer. This demonstrates the effectiveness of embryo freezing for improving IVF success rates.
Area of Science:
- Reproductive Medicine
- Embryology
- Cryobiology
Background:
- In vitro fertilization (IVF) programs generate surplus embryos.
- Cryopreservation of embryos is crucial for maximizing IVF success and patient options.
- Effective cryoprotective agents are essential for successful embryo freezing and thawing.
Purpose of the Study:
- To evaluate the efficacy of embryo cryopreservation and subsequent transfer.
- To determine pregnancy rates following the transfer of frozen-thawed surplus embryos.
- To assess the success of propanediol and glycerol as cryoprotectants in IVF.
Main Methods:
- 'Surplus' embryos from 28 IVF patients were cryopreserved using either propanediol or glycerol.
- Embryos were thawed and transferred in subsequent cycles for 20 patients.
- Pregnancy outcomes were tracked and analyzed.
Main Results:
- Embryo survival post-thawing was achieved in 20 patients.
- Five pregnancies resulted from embryo transfers (2 twin, 3 singleton).
- A pregnancy rate of 25% per embryo transfer was observed.
Conclusions:
- Embryo cryopreservation using propanediol or glycerol is an effective method in IVF.
- Frozen-thawed embryo transfer can lead to successful pregnancies.
- This technique enhances the overall success and efficiency of in vitro fertilization programs.