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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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Venous Thrombosis I: Introduction01:30

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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

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Related Experiment Video

Updated: May 13, 2026

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

The sticky platelet syndrome.

Benjamín Moncada1, Guillermo J Ruíz-Arguelles, Claudio Castillo-Martínez

  • 1Hospital Central ‘Ignacio Morones Prieto’, Internal Medicine Division, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México. moncadab@uaslp.mx

Hematology (Amsterdam, Netherlands)
|February 26, 2013
PubMed
Summary

Sticky Platelets Syndrome (SPS) is a congenital procoagulant disorder causing thrombi due to hyperactive platelets. Diagnosis relies on functional aggregometry, identifying it as a key consideration in thrombophilia evaluations.

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Last Updated: May 13, 2026

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

Area of Science:

  • Hematology
  • Genetics
  • Clinical Medicine

Background:

  • Sticky Platelets Syndrome (SPS) is a procoagulant condition characterized by hyperesponsive and hyperaggregable platelets.
  • It can lead to arterial, venous, or capillary thrombi and often remains asymptomatic until triggered by stress or other factors.
  • SPS is a congenital disorder with autosomal dominant inheritance, stemming from a defect in platelet function.

Purpose of the Study:

  • To describe the characteristics, classification, and diagnostic methods of Sticky Platelets Syndrome.
  • To highlight the importance of considering SPS in patients presenting with thrombophilia.

Main Methods:

  • Classification based on platelet reactivity to epinephrine and adenosine diphosphate (ADP).
  • Diagnosis confirmed using a functional aggregometer assay.

Main Results:

  • Platelet hyperaggregability is observed when challenged with epinephrine and ADP.
  • Three types of SPS are recognized based on reactivity to ADP and epinephrine: SPS type 1 (both), SPS type 2 (epinephrine only), and SPS type 3 (ADP only).

Conclusions:

  • SPS is a significant cause of thrombophilia due to a congenital platelet defect.
  • Functional aggregometry is crucial for diagnosis.
  • SPS should be considered in the differential diagnosis of patients with thrombophilia.