Related Experiment Video
Updated: May 13, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
Oocyte in vitro maturation in normo-ovulatory women
Rubens Fadini1, Mario Mignini Renzini, Mariabeatrice Dal Canto
1Biogenesi Reproductive Medicine Center, Istituti Clinici Zucchi, Monza, Italy.
Objective:
To review the scientific literature concerning the application of oocyte in vitro maturation (IVM) as a treatment for normo-ovulatory women.
Design:
Critical evaluation and comparison of the most relevant clinical studies.
Setting:
Public IVF unit.
Patient(S):
Normo-ovulatory women.
Intervention(S):
Oocyte IVM and cryopreservation.
Main Outcome Measure(S):
Maturation, fertilization, implantation, and pregnancy rates.
Result(S):
Maturation rates in vitro are suboptimal and influenced by several factors. IVM oocytes fertilize and undergo development in vitro with rates similar to in vivo matured control oocytes. In IVM cycles implantation and pregnancy rates are lower compared with controlled ovarian stimulation treatments, but accurate patient selection can improve IVM clinical outcome.
Conclusion(S):
In normal responders, IVM does not reach success rates similar to conventional ovarian stimulation regimens. However, it represents a milder approach to assisted reproduction treatment and an alternative intervention for specific conditions.
Related Concept Videos
Oogenesis
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...
Oogenesis
Folliculogenesis
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Ovarian Cycle
