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Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Reproductive Cloning

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...

Reproductive Cloning

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Related Experiment Video

Updated: May 13, 2026

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

Stem cell clonality -- theoretical concepts, experimental techniques, and clinical challenges.

Ingmar Glauche¹, Leonid Bystrykh, Connie Eaves

¹Institute for Medical Informatics and Biometry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany.

Blood Cells, Molecules & Diseases

|February 26, 2013

Summary

This workshop explored stem cell organization and clonality, focusing on hematopoietic stem cells. Discussions highlighted methods for quantifying stem cell clones and their dynamics in health and disease.

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Last Updated: May 13, 2026

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

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Area of Science:

Stem cell biology
Tissue regeneration
Hematopoietic system

Background:

International workshop on Stem Cell Organization (StemCellMathLab 2012) focused on clonality studies.
32 scientists from 8 countries with diverse backgrounds attended.
Previous workshops aimed to foster interdisciplinary discussions on stem cell biology.

Purpose of the Study:

Survey state-of-the-art methods and results in stem cell clonality research.
Address heterogeneity of stem cells and their progeny.
Differentiate clonal dynamics in physiological versus pathophysiological states.

Main Methods:

Focus on methods for quantifying clones and their dynamics in experimental and clinical settings.
Discussion of general concepts and models for describing clonal dynamics.
Systematic survey of current clonality research.

Main Results:

Exploration of clonal heterogeneity in unperturbed tissues.
Analysis of clonal dynamics under physiological and pathophysiological pressures.
Identification of conceptual and technical challenges in clone quantification.

Conclusions:

An interactive, cross-disciplinary approach is crucial for advancing stem cell research.
Improved understanding of tissue organization through continued research.
Need for clearly defined terminology in clonality research.