Related Experiment Video
Updated: May 13, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis
Janaína Souza Ventura1, Fernanda Faria, Isabel Fátima Correia Batista
1Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil.
Abstract:
Cancer is linked to hypercoagulability, and many studies have shown that anticoagulant drugs affect tumor progression. In this study was demonstrated that the Amblyomin-X (which is a recombinant protein that exerts similarity to the Kunitz-type inhibitors and shows pro-apoptotic effects in different tumor cell lines) and heparin (a classic anticoagulant) have similar effects on cancer progression and on normalization of the hypercoagulable state. However, Amblyomin-X showed a distinct mechanism in triggering its effects in vitro, because it exerted a cytotoxic effect in cancer cells by inducing apoptosis and promoting cell cycle arrest.
Related Concept Videos
The Intrinsic Apoptotic Pathway
The Extrinsic Apoptotic Pathway
Regulation of Angiogenesis and Blood Supply
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Intracellular Signaling Affects Focal Adhesions
Some...