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Related Experiment Video

Updated: May 13, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Distant white-matter diffusion changes caused by tumor growth.

Amir Zolal¹, Ales Hejcl, Alberto Malucelli

¹Department of Neurosurgery, J.E. Purkinje University, Masaryk Hospital, Socialni pece 12A, 401 00, Usti nad Labem, Czech Republic. amirzolal@gmail.com

Journal of Neuroradiology = Journal De Neuroradiologie

|February 26, 2013

Summary

This summary is machine-generated.

Brain tumors like glioblastomas and metastases impact distant white matter. Diffusion tensor imaging (DTI) revealed significant diffusion changes in the pyramidal tract, even far from the tumor, indicating subtle white matter alterations.

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Area of Science:

Neuroimaging
Oncology
Neurology

Background:

Conventional imaging may miss subtle white matter involvement near tumors.
Understanding distant white matter effects is crucial for accurate diagnosis and prognosis.

Purpose of the Study:

To investigate the distant effects of glioblastomas and metastases on white matter using diffusion tensor imaging (DTI).

Main Methods:

Analyzed DTI data from 21 patients with glioblastoma or metastasis.
Placed regions of interest (ROIs) along pyramidal tracts distant from the tumor (>15 mm).

Main Results:

Significantly lower fractional anisotropy (FA) ipsilateral to the tumor in all patients and subgroups.
Increased trace values ipsilateral to the tumor in the general population and metastasis subgroup.
Diffusion changes correlated with motor deficits.

Conclusions:

Glioblastomas and metastases induce observable diffusion changes in distant white matter tracts.
These changes occur without conventional signal abnormalities and differ between tumor types.
Mechanisms beyond Wallerian degeneration likely contribute to observed white matter alterations.