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Updated: May 13, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Pyridine to aniline: an exceptional biologically driven rearrangement
Thomas Arnauld1, Jean-Yves Beaumal, François Lefoulon
1Synthesis Department, Technologie Servier, 27 Rue Eugène Vignat, 45000 Orléans, France. thomas.arnauld@fr.netgrs.com
Abstract:
During the course of our study on the innovative ligand for nicotinic acetylcholinergic receptors, LNAChR, and in order to assess activity and toxicity profiles of the drug's metabolites, synthesis of the main metabolites was undertaken. This synthesis work was done in parallel by organic chemistry and by biotransformation of LNAChR. Filamentous fungus Aspergillus alliaceus (NRRL 315) neatly afforded three of the main metabolites, one of which arose from a very unexpected and very uncommon rearrangement.
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