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General Anesthesia: Overview

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...

Local Anesthetics: Clinical Application as Spinal Anesthesia

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

Local Anesthetics: Clinical Application as Epidural Anesthesia

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...

Local Anesthetics: Common Agents and Their Applications

Local Anesthetics: Common Agents and Their Applications

Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...

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Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

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Neuroanesthesiology update.

Jeffrey J Pasternak¹, William L Lanier

¹Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. pasternak.jeffrey@mayo.edu

Journal of Neurosurgical Anesthesiology

|February 26, 2013

Summary

This summary is machine-generated.

This review covers 2012 clinical and basic science literature on neurological disease care, focusing on innovative concepts in neurosurgery, stroke, and brain injury. It highlights neuroprotection and monitoring for clinicians and neuroscientists.

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Area of Science:

Neurology
Neurosurgery
Neuroscience

Background:

The year 2012 saw significant advancements in understanding and treating neurological disorders.
Clinical and basic science research continually evolves, necessitating regular reviews to synthesize new findings.

Purpose of the Study:

To review key clinical and basic science literature from 2012 pertinent to neurological disease patient care.
To identify and summarize innovative concepts and recurring themes in the field.

Main Methods:

Comprehensive literature search of clinical and basic science publications from 2012.
Thematic analysis of research focusing on neurosurgical procedures, stroke, traumatic brain injury, spine surgery, anesthetic neurotoxicity, neuroprotective strategies, and electrophysiological monitoring.

Main Results:

Identification of novel approaches in general neurosurgery, stroke management, and traumatic brain injury treatment.
Emerging trends in spine surgery, anesthetic neurotoxicity, and the application of neuroprotective strategies were noted.
Advances in electrophysiological monitoring techniques and discussions on medical education were also prominent.

Conclusions:

The 2012 literature reflects a dynamic research landscape with innovative developments across various subspecialties of neurology and neurosurgery.
Synthesized findings provide valuable insights for both clinical practitioners and neuroscientists engaged in neurological disease research.