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Related Experiment Video

Updated: May 13, 2026

Fabrication And Characterization Of Photonic Crystal Slow Light Waveguides And Cavities
11:08

Fabrication And Characterization Of Photonic Crystal Slow Light Waveguides And Cavities

Published on: November 30, 2012

Selective virus detection in complex sample matrices with photonic crystal optical cavities.

Sudeshna Pal1, Amrita R Yadav, Mark A Lifson

  • 1Department of Electrical & Computer Engineering, University of Rochester, Rochester, New York 14627, USA.

Biosensors & Bioelectronics
|February 26, 2013
PubMed
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This study introduces a novel photonic crystal waveguide biosensor for rapid, label-free virus detection. The sensor achieved a 1.5 nM detection limit for Human Papillomavirus virus-like particles in complex samples.

Area of Science:

  • Nanophotonics
  • Biosensing
  • Optical detection

Background:

  • Accurate virus detection is crucial for public health and safety.
  • Existing methods can be slow, costly, or require sample labeling.

Purpose of the Study:

  • To develop a sensitive and selective label-free biosensor for virus detection.
  • To demonstrate the application of a W1 photonic crystal waveguide for virus detection.

Main Methods:

  • Fabrication of a silicon-on-insulator photonic crystal waveguide biosensor using e-beam lithography and reactive-ion-etching.
  • Optical detection based on resonant mode shifts due to refractive index changes.
  • Finite difference time domain (FDTD) calculations for sensor design and validation.

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Last Updated: May 13, 2026

Fabrication And Characterization Of Photonic Crystal Slow Light Waveguides And Cavities
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Fabrication And Characterization Of Photonic Crystal Slow Light Waveguides And Cavities

Published on: November 30, 2012

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

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DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning

Published on: May 10, 2024

Main Results:

  • Achieved a limit of detection of 1.5 nM for Human Papillomavirus virus-like particles (VLPs).
  • Demonstrated effective detection in both simple buffer and complex 10% fetal bovine serum matrices.
  • Showcased high selectivity for intact VLPs using specific anti-VLP antibodies.

Conclusions:

  • The W1 photonic crystal waveguide biosensor offers a promising platform for sensitive, selective, and label-free virus detection.
  • This technology has potential applications in medical diagnostics, biosecurity, and environmental monitoring.