Related Experiment Video
Updated: May 13, 2026

10:55
Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
Published on: October 31, 2025
A fatal presentation of dermatomyositis
P Khatiwoda1, S R Kayastha, P Khatiwada
1Media and Research Department, Richa Bajimaya Memorial Foundation.
Kathmandu University Medical Journal (KUMJ)
|February 26, 2013
Summary
Dermatomyositis, an autoimmune condition, can manifest with skin lesions and muscle weakness. Early diagnosis and aggressive immunosuppressive therapy are crucial for managing associated vasculopathies.
Area of Science:
- Autoimmune diseases
- Dermatology
- Rheumatology
Background:
- Dermatomyositis (DM) is a rare autoimmune disorder impacting skin, muscles, and lungs.
- The exact mechanisms behind skin inflammation in DM remain unclear.
Observation:
- A 40-year-old male presented with a four-month history of widespread skin lesions, pain, and muscle weakness.
- Laboratory tests revealed elevated transaminases, indicating potential muscle damage.
- Clinical examination confirmed significant muscle weakness.
Findings:
- The case underscores the importance of considering dermatomyositis in patients presenting with concurrent skin lesions and muscle weakness.
- Elevated transaminases and muscle weakness are key indicators in diagnosing DM.
Implications:
- Prompt diagnosis of dermatomyositis is essential for initiating timely treatment.
- Aggressive immunosuppressive therapies may be necessary to manage DM-associated vasculopathies and prevent complications.
Related Concept Videos
Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Diphtheria
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...