Related Experiment Video

Updated: May 13, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

Bioavailability of phytochemicals and its enhancement by drug delivery systems

Farrukh Aqil1, Radha Munagala1, Jeyaprakash Jeyabalan1

  • 1James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, United States.

Cancer Letters
|February 26, 2013
PubMed

Insights

Poor oral bioavailability of cancer chemopreventives limits their effectiveness. Novel drug delivery systems, including nanoparticles and liposomes, are improving cancer prevention by enhancing drug delivery and bioavailability.

Area of Science:

  • Pharmaceutical Sciences
  • Oncology
  • Drug Delivery Systems

Background:

  • Poor oral bioavailability of cancer chemopreventive agents is a significant challenge in cancer prevention research.
  • Effective delivery of chemopreventives to target sites is crucial for successful cancer prevention strategies.

Purpose of the Study:

  • To review novel drug delivery systems for enhancing the bioavailability and efficacy of cancer chemopreventives.
  • To discuss the impact of advanced delivery systems on cancer prevention and treatment.

Main Methods:

  • Review of existing literature on drug delivery systems for cancer chemopreventives.
  • Analysis of various delivery approaches, including nanoparticles, cyclodextrins, niosomes, liposomes, and implants.
  • Discussion of pharmacokinetic modulation by novel delivery systems.

Main Results:

  • Novel delivery systems significantly enhance the bioavailability of chemopreventive agents.
  • These systems can effectively deliver drugs to target tissues, improving therapeutic outcomes.
  • Examples of successful delivery approaches that have demonstrated substantial bioavailability increases are highlighted.

Conclusions:

  • Advanced drug delivery systems offer promising solutions to overcome the limitations of oral bioavailability for cancer chemopreventives.
  • The development of new delivery systems is essential for advancing cancer prevention and treatment strategies.
  • Targeted delivery and enhanced bioavailability are key to maximizing the potential of chemopreventive agents.

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability: Influencing Factors01:22

Bioavailability: Influencing Factors

Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...