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[Liquid embolic agents--Onyx as problem solver].

W A Wohlgemuth1, W Uller, R Müller-Wille

  • 1Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 1, Regensburg, Germany. walter.wohlgemuth@ukr.de

Der Radiologe
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Summary
This summary is machine-generated.

Onyx, a liquid embolic agent, offers controlled administration for permanent capillary occlusion. While effective, its high cost and dimethyl sulfoxide (DMSO) solvent present challenges in embolotherapy applications.

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Area of Science:

  • Interventional Radiology
  • Biomaterials Science

Background:

  • Liquid embolic agents are crucial for permanent capillary occlusion.
  • Conventional agents like ethanol and Histoacryl have limitations in administration and safety.

Purpose of the Study:

  • To evaluate Onyx, a liquid embolic agent, for its properties and applications in embolotherapy.
  • To highlight the advantages and disadvantages of Onyx compared to conventional agents.

Main Methods:

  • Onyx is composed of ethylene vinyl alcohol copolymer, dimethyl sulfoxide (DMSO), and micronized tantalum powder.
  • Its physicochemical properties enable controlled application and visualization via fluoroscopy.

Main Results:

  • Onyx allows for controlled application, forming a defined cast for permanent occlusion.
  • While primarily used in neuroradiology, peripheral applications are increasing.
  • Disadvantages include high cost and DMSO-related issues like special catheter requirements and patient discomfort.

Conclusions:

  • Onyx is a viable option for embolotherapy, particularly for endoleaks, arterial bleeding, and arteriovenous malformations.
  • Further research may address cost and solvent-related challenges to broaden its utility.