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Complications of targeted drug therapies for solid malignancies: manifestations and mechanisms

Richard G Abramson1, Vandana G Abramson, Emily Chan

  • 1Department of Radiology and Radiological Science, Vanderbilt University School of Medicine, 1161 21st Ave S, CCC-1121 MCN, Nashville, TN 37232-2675, USA. richard.abramson@vanderbilt.edu

AJR. American Journal of Roentgenology
|February 26, 2013
PubMed
Abstract

Insights

This review covers imaging findings of targeted therapy complications in solid tumors. Understanding drug toxicities helps differentiate side effects from disease progression, aiding in patient management.

Area of Science:

  • Oncology
  • Radiology
  • Pharmacology

Background:

  • Targeted drug therapies are increasingly used for solid malignancies.
  • These therapies can cause unique complications identifiable on diagnostic imaging.
  • Differentiating drug effects from disease progression is clinically significant.

Purpose of the Study:

  • To review key complications of targeted drug therapies for solid tumors.
  • To correlate imaging findings with specific drug toxicities.
  • To emphasize known or proposed mechanistic explanations for these drug complications.

Main Methods:

  • Literature review of diagnostic imaging findings.
  • Analysis of complications associated with targeted cancer therapies.
  • Emphasis on mechanistic explanations for observed toxicities.

Main Results:

  • Detailed descriptions of imaging manifestations of drug toxicities.
  • Association of specific complications with particular targeted agents.
  • Discussion of underlying mechanisms contributing to drug-induced complications.

Conclusions:

  • Knowledge of targeted therapy toxicity profiles is crucial for radiologists and oncologists.
  • Diagnostic imaging plays a vital role in identifying drug-related complications.
  • Mechanistic understanding aids in associating drugs with complications and predicting future toxicities.

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