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Related Concept Videos

Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

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Related Experiment Video

Updated: May 13, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Internet-based screening for dementia risk.

Jason Brandt1, Campbell Sullivan, Larry E Burrell

  • 1Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. jbrandt@jhmi.edu

Plos One
|February 26, 2013
PubMed
Summary
This summary is machine-generated.

The Dementia Risk Assessment (DRA) tool effectively identifies dementia risk factors and cognitive decline using memory tests and informant reports. It shows promise for widespread dementia screening and early clinical evaluation.

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The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
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The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Related Experiment Videos

Last Updated: May 13, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Area of Science:

  • Gerontology
  • Neuroscience
  • Public Health

Background:

  • Dementia poses a significant global health challenge, necessitating accessible screening tools.
  • Early identification of dementia risk factors and cognitive decline is crucial for timely intervention.
  • Existing screening methods may not fully capture the multifaceted nature of dementia risk.

Purpose of the Study:

  • To evaluate the Dementia Risk Assessment (DRA) as an online tool for identifying dementia risk.
  • To assess the DRA's ability to detect cognitive decline and differentiate dementia from other conditions.
  • To explore the utility of the DRA for public education and encouraging clinical evaluation.

Main Methods:

  • Study 1: Over 3,000 individuals over 50 completed the DRA, including self-assessments and proxy reports.
  • Study 2: 52 patients at dementia clinics completed the DRA before clinical evaluation by neuropsychiatrists.
  • Analysis involved correlating DRA results with memory test performance and clinical diagnoses.

Main Results:

  • Advanced age, lower education, cerebrovascular disease, and memory complaints significantly predicted poor memory performance in Study 1.
  • Proxy reports strongly correlated with actual memory test results.
  • In Study 2, the DRA differentiated patients with probable Alzheimer's, vascular, or frontotemporal dementia from those without dementia.

Conclusions:

  • The Dementia Risk Assessment (DRA) demonstrates potential as a valid tool for screening dementia risk factors and cognitive decline.
  • The DRA's memory test shows moderate predictive validity for clinically diagnosed dementia.
  • Further research with larger clinical samples is warranted, but the DRA shows promise for wide-scale dementia risk screening.