Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic factors and survival outcomes in relapsed/refractory aggressive B-cell lymphomas treated with epcoritamab.

Blood advances·2026
Same author

Chimeric Antigen Receptor T-Cell Therapy in Autoimmune Disorders: An Expert Panel Opinion From the American Society for Transplantation and Cellular Therapy.

Transplantation and cellular therapy·2026
Same author

Outcomes of hematopoietic stem cell transplantation in patients aged 70 years and older.

Bone marrow transplantation·2026
Same author

Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates.

Nature communications·2026
Same author

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma-Like Transcriptional Programs in Astrocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Tailored Phosphate Leaving Groups Direct Pathway-Dependent Self-Assembly.

Journal of the American Chemical Society·2026

Related Experiment Video

Updated: May 13, 2026

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

Surface functionality as a means to impact polymer nanoparticle size and structure.

Julia Schneider1, Andrew P Jallouk, Daniela Vasquez

  • 1Institute for Macromolecular Chemistry, University of Freiburg, Freiburg, Germany.

Langmuir : the ACS Journal of Surfaces and Colloids
|February 27, 2013
PubMed
Summary
This summary is machine-generated.

Controlling nanoparticle size during nanoprecipitation is achieved by adding polyelectrolytes (PEs). Hydrogen-bonding PEs reduce size, while others increase it, offering a new method for nanoparticle production.

More Related Videos

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

Nanosponge Tunability in Size and Crosslinking Density
11:15

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

Related Experiment Videos

Last Updated: May 13, 2026

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

Nanosponge Tunability in Size and Crosslinking Density
11:15

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Nanoparticle (NP) size control during nanoprecipitation typically relies on adjusting polymer concentration or solvent composition.
  • This process involves nucleation and growth, making precise size management challenging.

Purpose of the Study:

  • To demonstrate a novel method for controlling nanoparticle size independent of polymer variables.
  • To investigate the role of polyelectrolytes (PEs) in modulating NP size during nanoprecipitation.

Main Methods:

  • Introduction of polyelectrolytes (PEs) into the aqueous phase during NP formation.
  • Utilizing nanoprecipitation, a nucleation-growth process.
  • Characterizing the effect of PEs with and without hydrogen bonding (H-bonding) capabilities on NP size.

Main Results:

  • Polyelectrolytes enabled NP size control independently of polymer concentration or solvent composition.
  • PEs exhibiting H-bonding resulted in smaller NPs.
  • PEs lacking H-bonding characteristics led to the formation of larger NPs.
  • A dense shell formation around NPs, acting as a diffusional barrier, was identified as the underlying mechanism.

Conclusions:

  • Polyelectrolyte addition offers a versatile strategy for tuning nanoparticle size during nanoprecipitation.
  • The presence or absence of hydrogen bonding in PEs dictates the resulting nanoparticle size.
  • This principle is applicable to both polymeric and lipid nanoparticles, broadening its utility in nanomaterial synthesis.