Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

Schizophrenia

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

Psychological and Sociocultural Causes of Schizophrenia

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

Psychosis and Antipsychotic Drugs: Overview

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low salivary thioredoxin-1 levels in periodontitis.

World journal of clinical cases·2026

Same author

Exposure to respirable desert dust entering indoors prompts quick oxidative-stress and inflammatory responses in the airways of chronic heart failure patients.

Scientific reports·2025

Same author

Clinical Personality Patterns in Alcohol Use Disorder: A Study Focused on Sex Differences.

Journal of clinical medicine·2025

Same author

Low salivary uric acid levels are independently associated with periodontitis.

World journal of clinical cases·2025

Same author

Serum 3-Nitrotyrosine in the Cardiovascular Disease of Patients with Systemic Lupus Erythematosus.

Antioxidants (Basel, Switzerland)·2025

Same author

Relationship of Serum 3-Nitrotyrosine Levels with Inflammation in Patients with Rheumatoid Arthritis.

Diagnostics (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: May 13, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

S100B and schizophrenia.

Silvia Yelmo-Cruz¹, Armando L Morera-Fumero, Pedro Abreu-González

¹Department of Psychiatry, University Hospital of the Canary Islands, La Laguna, Spain. silviayelmo@gmail.com

Psychiatry and Clinical Neurosciences

|February 27, 2013

Summary

Schizophrenia patients consistently show higher S100B protein levels than healthy individuals. However, S100B

Area of Science:

Neuroscience
Biochemistry
Psychiatry

Background:

Peripheral biological markers for schizophrenia remain largely elusive.
S100B protein, a calcium-binding protein, is investigated as a potential marker for astrocyte activation and brain dysfunction.

Purpose of the Study:

To review the current research on S100B protein concentrations in relation to schizophrenia.
To identify factors contributing to the variability in S100B research findings.

Main Methods:

Literature review of studies investigating S100B protein levels in schizophrenia patients.
Analysis of correlations between S100B levels and schizophrenia diagnosis, subtypes, clinical characteristics, and psychopathology.

Main Results:

More Related Videos

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

Related Experiment Videos

Last Updated: May 13, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

Consistent elevation of S100B protein concentrations in patients with schizophrenia compared to healthy controls.
Inconclusive findings regarding the correlation of S100B levels with schizophrenia subtypes, clinical characteristics (age, BMI, illness duration, age at onset), and psychopathology (positive/negative symptoms).

Conclusions:

While S100B protein shows promise as a diagnostic marker for schizophrenia, its association with clinical and psychopathological features is not well-established.
Methodological factors such as sample collection, analytical techniques, and symptom assessment scales contribute to result variability and require standardization for future research.