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Updated: May 13, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
Published on: May 21, 2017
Aortic valve replacement for aortic stenosis caused by alkaptonuria.
Junko Hiroyoshi1, Aya Saito, Nirmal Panthee
1Department of Cardiothoracic Surgery, the University of Tokyo, Faculty of Medicine, Tokyo, Japan.
This case study details a 70-year-old man with aortic stenosis and ochronosis who received a biologic aortic valve replacement. Intraoperative findings revealed a calcified, pigmented aortic valve and aortic intima consistent with ochronosis.
Area of Science:
- Cardiology
- Genetics
- Pathology
Background:
- Ochronosis is a rare metabolic disorder characterized by the deposition of homogentisic acid, leading to tissue pigmentation.
- Aortic stenosis is a common valvular heart disease, often associated with calcification and aging.
- The association between ochronosis and aortic stenosis is infrequently reported, making this case noteworthy.
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