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Updated: May 13, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Importance of receptor-targeted systems in the battle against atherosclerosis

Elisabet Rosas1, Igor Sobenin, Alexander Orekhov

  • 1Massachusetts Institute of Technology, Harvard-MIT Biomedical Engineering Center, 77 Massachusetts Avenue, E25-438, Cambridge, MA 02139, US. merche@mit.edu.

Current Pharmaceutical Design
|February 27, 2013
PubMed

Insights

This review highlights new methods for early atherosclerosis detection and targeted treatments. Research focuses on identifying endothelial dysfunction and imaging advanced plaques for better patient outcomes.

Area of Science:

  • Cardiovascular Research
  • Medical Imaging
  • Translational Medicine

Background:

  • Atherosclerosis is a major cause of mortality globally.
  • Current research lacks reliable early diagnostic markers and targeted therapies.
  • Existing studies often focus on cellular and animal models.

Purpose of the Study:

  • To review recent advancements in detecting early-stage atherosclerosis.
  • To summarize strategies for imaging and targeting advanced atherosclerotic plaques.
  • To bridge the gap between research findings and clinical applications.

Main Methods:

  • Literature review of recent studies on endothelial dysfunction.
  • Analysis of novel imaging techniques for atherosclerotic plaques.
  • Evaluation of emerging therapeutic strategies for atherosclerosis.

Main Results:

  • Early detection of endothelial dysfunction shows promise for asymptomatic atherosclerosis.
  • Advanced imaging techniques offer new ways to visualize plaque progression.
  • Targeted therapies are being developed to address specific plaque characteristics.

Conclusions:

  • Early detection and targeted interventions are crucial for managing atherosclerosis.
  • Continued research in imaging and therapeutics can improve patient outcomes.
  • Translating research findings into clinical practice remains a key challenge.

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