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Related Experiment Video

Updated: May 13, 2026

A Mouse Model of Ankle-Subtalar Complex Joint Instability
09:14

A Mouse Model of Ankle-Subtalar Complex Joint Instability

Published on: October 28, 2022

Acute ankle sprain in a mouse model.

Tricia Hubbard-Turner1, Erik A Wikstrom, Sophie Guderian

  • 1Biodynamics Research Laboratory, Department of Kinesiology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA. thubbar1@uncc.edu

Medicine and Science in Sports and Exercise
|February 27, 2013
PubMed
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This study developed a mouse model for ankle sprains, revealing that transecting ankle ligaments significantly impacts running performance and balance. This model aids in understanding long-term ankle instability consequences.

Area of Science:

  • Orthopedics
  • Biomechanics
  • Animal Models

Background:

  • Ankle sprains are common, but long-term human studies are challenging and costly.
  • The long-term consequences of ankle sprains are not fully understood.
  • A reliable animal model is needed to study ankle sprain pathology.

Purpose of the Study:

  • To develop and validate a mechanical ankle instability model in mice.
  • To investigate the effects of specific ligament transections on ankle function.
  • To establish a preclinical tool for studying ankle sprain sequelae.

Main Methods:

  • Thirty male CBA/2J mice were divided into transected anterior talofibular ligament/calcaneal fibular ligament (ATFL/CFL), transected CFL only, and SHAM groups.
  • Mechanical instability was induced via ligament transection.

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  • Running wheel activity (duration, distance, speed), balance (slips), and gait (stride length) were assessed for 4 weeks post-surgery.

    • Main Results:

    • The ATFL/CFL group showed significantly reduced running duration, distance, and speed compared to SHAM mice in week 1.
    • Both ATFL/CFL and CFL-only groups exhibited increased slips during balance tests post-surgery.
    • Gait analysis revealed shorter stride lengths in the involved limb for both surgical groups compared to SHAM.

    Conclusions:

    • A mouse model successfully induces mechanical ankle instability.
    • This model allows for the investigation of functional deficits following ankle ligament injury.
    • The findings support the utility of this mouse model for studying long-term ankle instability.