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Preparation of Human Myocardial Tissue for Long-Term Cultivation

Preparation of Human Myocardial Tissue for Long-Term Cultivation

Published on: June 2, 2022

Cardiovascular tissue banking in Europe.

T M M H de By¹, R Parker, E M Delmo Walter

¹Foundation of European Tissue Banks, Berlin.

HSR Proceedings in Intensive Care & Cardiovascular Anesthesia

|February 27, 2013

Summary

European cardiovascular tissue banks supply heart valves for surgery, but face challenges. Data shows fluctuating demand for allografts and varied decontamination methods, indicating a need for improvement.

Keywords:

cardiovascular tissue contamination decontamination discard rate homograft microbiology ross operation serology tissue bank tissue donor validation

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Area of Science:

Cardiovascular Surgery
Tissue Banking
Transplantation Immunology

Background:

Human cardiovascular tissue allografts (homografts) have been used for 50 years to treat valvular diseases.
The number of cardiovascular tissue banks and their techniques has increased.
A survey was conducted to quantify allografts processed and issued by European tissue banks.

Purpose of the Study:

To establish the quantity of cardiovascular allografts processed and issued by European tissue banks.
To collect other relevant statistics regarding cardiovascular tissue banking.

Main Methods:

Data collected in 2011 from 19 cardiovascular tissue banks across 11 European countries.
Analysis of data from 2007 to 2010.

Main Results:

A decrease in received hearts (1700 to 1640) and processing per bank (113 to 91) from 2007-2010.
An increase in heart valves issued for transplantation (1272 to 1486) from 2007-2010.
High discard rates: 20.7% for microbiological contamination, 4.2% for positive serology. Significant differences in decontamination methods were observed.

Conclusions:

Cardiovascular tissue banks are integral to cardiovascular surgery.
Fluctuating demand for allografts and methodological variations in decontamination present challenges.
There is a need for improved validation of decontamination methods in tissue banking.