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High-sensitivity C-reactive protein (hs-CRP) and tumor necrotizing factor-alpha (TNF-alpha) after on- and off- pump

H Javadzadegan1, N Nezami, K Ghobadi

  • 1Department of Cardiology, Tabriz University (Medical Sciences), Tabriz, Iran.

HSR Proceedings in Intensive Care & Cardiovascular Anesthesia
|February 27, 2013
PubMed

Insights

Coronary artery bypass grafting (CABG) surgery increases high-sensitivity C-reactive protein (hs-CRP) levels. However, this study found no significant differences in hs-CRP or tumor necrosis factor-alpha between on-pump and off-pump CABG procedures.

Area of Science:

  • Cardiovascular Surgery
  • Inflammatory Biomarkers
  • Cardiac Surgery Outcomes

Background:

  • Coronary artery bypass grafting (CABG) is a common surgical procedure worldwide.
  • Inflammatory markers like hs-CRP and TNF-alpha are implicated in cardiac surgery.
  • Comparing on-pump versus off-pump CABG is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To investigate the differences in hs-CRP and TNF-alpha levels between on-pump and off-pump CABG.
  • To assess the impact of surgical technique on systemic inflammation post-CABG.

Main Methods:

  • Prospective study involving 90 patients undergoing CABG.
  • Measurement of hs-CRP and TNF-alpha using ELISA kits.
  • Comparison of biomarker levels between on-pump and off-pump surgical groups.

Main Results:

  • hs-CRP levels significantly increased after CABG (p<0.001).
  • No significant differences in hs-CRP levels were observed between on-pump and off-pump groups (p=0.4).
  • No significant differences in TNF-alpha levels were observed between on-pump and off-pump groups (p=0.8).

Conclusions:

  • Surgical approach (on-pump vs. off-pump) does not appear to influence post-CABG hs-CRP or TNF-alpha levels.
  • Both surgical techniques result in comparable inflammatory responses based on these biomarkers.
  • Further research may explore other inflammatory mediators or long-term outcomes.
Abstract

Keywords:
C-reactive protein (CRP)cardiopulmonary bypasscoronary artery bypass graftingoff-pumpon-pumptumor necrotizing factor-alpha (TNF-alpha)

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