Cardiac pacing in paediatric patients with congenital heart defects: transvenous or epicardial?
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Massimo Stefano Silvetti1, Fabrizio Drago, Duccio Di Carlo
1Unità Operativa di Aritmologia/Syncope Unit, Dipartimento Medico-Chirurgico di Cardiologia Pediatrica Bambino Gesu` Children’s Hospital, IRCCS, Piazza S. Onofrio 4, 00165 Rome, Italy. silvetti@opbg.net
Insights
Pediatric cardiac pacing in congenital heart defects (CHDs) is challenging. Endocardial systems demonstrate superior long-term outcomes compared to epicardial systems, with younger implant age being a risk factor for complications.
Area of Science:
- Pediatric Cardiology
- Cardiac Electrophysiology
- Congenital Heart Disease
Background:
- Cardiac pacing in children with congenital heart defects (CHDs) presents unique challenges.
- Limited research exists on long-term outcomes of pacing in this population.
Purpose of the Study:
- To evaluate the long-term efficacy and safety of endocardial versus epicardial pacing systems in pediatric patients with CHDs.
- To identify risk factors for pacing system failure and complications in this cohort.
Main Methods:
- Retrospective analysis of 287 pediatric patients with CHDs who underwent cardiac pacing between 1982 and 2008.
- Comparison of outcomes between endocardial (Endo) and epicardial (Epi) pacing systems.
- Multivariate analysis to identify predictors of pacing system failure.
Main Results:
- Endocardial systems showed significantly lower failure rates (13%) compared to epicardial systems (40%) over a median follow-up of 5 years.
- Younger age at implantation and the use of epicardial systems were associated with a higher risk of pacing system failure.
- Steroid-eluting leads demonstrated a lower risk of malfunction, particularly in endocardial placements.
Conclusions:
- Cardiac pacing in pediatric patients with CHDs yields satisfactory long-term results.
- Endocardial pacing systems offer significantly better long-term outcomes than epicardial systems in this population.
- Younger age at implantation is a significant risk factor for long-term pacing complications.
Aims:
Cardiac pacing is a difficult technique in children, particularly in patients with congenital heart defects (CHDs). Few studies to date have addressed this topic.
Methods And Results:
We performed a retrospective analysis of the results of a single centre. Between 1982 and 2008, 287 patients with CHD, median age of 5 years (25-75%, 1-11) underwent cardiac pacing for sinus node dysfunction (SND) and atrioventricular block (AVB); 97% of patients underwent at least one heart surgery. Endocardial systems (Endo) were implanted in 117 patients, epicardial systems (Epi) in 170, with 595 leads (228 Endo, 367 Epi). Endocardial systems showed a significantly older age group with more frequent SND; Epi a younger age group, with more frequent AVB, greater number of surgical interventions. Perioperative complications were mortality 0.6% (Epi), pericardial effusion 0.6% (Epi), and haemothorax 3.4% (Endo). The median follow-up is 5 (2-10) years: the pacing system failed in 29% of patients, 13% Endo, and 40% Epi (P < 0.0001). Multivariate analysis showed a significantly higher risk of failure for Epi, a lower implant age, greater the number of leads implanted. The risk of malfunction of the leads increases significantly for Epi and the younger age when implanted. The steroid-eluting leads have a lower risk of malfunction (P = 0.05), steroid-eluting Endo leads provide significantly better outcomes than Epi.
Conclusion:
Cardiac pacing in paediatric patients with CHD shows satisfactory results in the long term. Endocardial systems show significantly better results than Epi systems. A younger age when implanted is a risk factor for complications at follow-up.
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