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Further Evidence for Celiac Disease-associated Chorea
1Departments of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, New York ; Mount Sinai School of Medicine, New York, United States of America.
Background:
A number of neurological conditions have been reported to be associated with gluten sensitivity, including ataxia, peripheral neuropathy, epilepsy, and occasionally, chorea. The pathogenic role of anti-gliadin antibodies has been questioned, and pathophysiology remains controversial.
Case Report:
I report chorea in a patient with celiac disease, which responded to a gluten-restricted diet. The response of the movement disorder to change in diet strongly suggests a functional role for anti-gliadin antibodies in the generation of chorea, probably involving basal ganglia targets.
Discussion:
Gluten sensitivity may be a treatable cause of chorea.
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