Depression associated with dysembryoblastic neuroepithelial tumor

Dysembryoblastic neuroepithelial tumor (DNET), a benign, rare tumor of the brain, commonly presents with generalized or partial epilepsy, post-epilepsy sequelae of psychotic, depressive or anxiety symptoms or disorders, or is usually asymptomatic. We report the first case in scientific literature of temporal lobe DNET presenting with only major depressive disorder, without epilepsy. A 24-year-old single male, presented with pervasive sadness, easy fatigability, loss of interest in his daily activities, decreasing appetite associated with poor of quality sleep, poor attention and concentration, pessimism about the future, and headaches. He was diagnosed with severe depression, without psychotic symptoms. Magnetic resonance imaging of the brain showed a lobulated hyperintense temporal lobe mass of 2.7 × 2.2 mm in the hippocampus region suggestive of a DNET. Electroencephalography, thyroid function tests, blood sugar, and electrocardiogram were normal. The depression responded well to tablet Escitalopram 10 mg once daily initially, with no adverse effects reported.