Depression associated with dysembryoblastic neuroepithelial tumor

Area of Science:

• Neuro-oncology
• Neurology
• Psychiatry

Background:

• Dysembryoplastic neuroepithelial tumors (DNETs) are rare, benign brain tumors.
• DNETs typically manifest as epilepsy or are asymptomatic.
• Associated symptoms can include psychotic, depressive, or anxiety disorders.

Observation:

• A 24-year-old male presented with symptoms of severe depression, including sadness, fatigue, anhedonia, sleep disturbance, and poor concentration.
• Brain MRI revealed a temporal lobe mass consistent with DNET.
• The patient had no history of epilepsy or psychotic symptoms.

Findings:

• This case represents the first documented instance of a temporal lobe DNET presenting exclusively with major depressive disorder.
• Electroencephalography and routine blood tests were normal.
• The patient's depression responded effectively to Escitalopram treatment.

Implications:

• This case expands the known clinical spectrum of DNET presentations.
• It underscores the importance of considering neuroimaging in patients with new-onset depression, especially when atypical symptoms are present.
• Highlights the potential for neurological conditions to manifest primarily as psychiatric disorders.