Related Experiment Video
Updated: May 13, 2026
11:14
Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
Wntless in Wnt secretion: molecular, cellular and genetic aspects
Soumyashree Das1, Shiyan Yu, Ryotaro Sakamori
1Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.
Frontiers in Biology
|February 27, 2013
Summary
Wntless is a key protein that transports Wnt proteins within cells, controlling their release and Wnt signaling. This review summarizes research affirming Wntless
Area of Science:
- Cell Biology
- Developmental Biology
- Molecular Biology
Background:
- Wnt signaling pathways are crucial for embryonic development and tissue maintenance across the animal kingdom.
- Wnt proteins function as morphogens, secreted extracellularly after modification into glycolipoproteins.
- Regulation of Wnt protein secretion is a complex process involving intracellular trafficking.
Purpose of the Study:
- To review the role of Wntless in the intracellular transport and secretion of Wnt proteins.
- To highlight recent cellular, molecular, and genetic findings on Wntless function.
- To underscore the importance of Wntless in regulating Wnt signaling levels.
Main Methods:
- Review of recent cellular studies.
- Analysis of molecular data.
- Examination of genetic research findings.
Main Results:
- Wntless is identified as a putative G-protein coupled receptor.
- Evidence supports Wntless's function in the intracellular transport of Wnt proteins.
- Wntless plays a critical role in the secretion of Wnt proteins.
Conclusions:
- Wntless is essential for the proper secretion of Wnt proteins.
- Understanding Wntless mechanisms provides insight into Wnt signaling regulation.
- Further research into Wntless is warranted to fully elucidate Wnt secretion pathways.
More Related Videos
Related Concept Videos
02:54Canonical Wnt Signaling Pathway
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
02:54Canonical Wnt Signaling Pathway
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
01:41Non-Canonical Wnt Signaling Pathways
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
01:41Non-Canonical Wnt Signaling Pathways
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...