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Updated: May 13, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Multiple causes for an ischemic stroke: myxoma, papillary fibroelastomas and patent foramen ovale
J Roque1, F Silva, R Arruda Pereira
1Department of Cardiothoracic Surgery, Hospital de Santa Maria, Lisbon, Portugal.
Insights
This case highlights a rare combination of cardiac tumors, including myxoma and multiple papillary fibroelastomas, alongside a patent foramen ovale, all contributing to ischemic stroke. Intraoperative echocardiography proved crucial for diagnosis and surgical planning.
Area of Science:
- Cardiology
- Cardiac Surgery
- Vascular Neurology
Background:
- Ischemic vascular accidents (strokes) can arise from various underlying pathologies.
- Rare cardiac tumors, such as myxoma and fibroelastomas, can embolize, leading to stroke.
- Patent foramen ovale is a known risk factor for cryptogenic stroke.
Observation:
- A patient presented with acute stroke symptoms.
- Diagnostic workup revealed a left atrial myxoma and a patent foramen ovale.
- Intraoperative transesophageal echocardiography identified multiple papillary fibroelastomas on the aortic valve.
Findings:
- The patient had a rare coexistence of a left atrial myxoma and multiple aortic valve papillary fibroelastomas, along with a patent foramen ovale.
- This combination of uncommon embolic sources presented a unique diagnostic and management challenge.
- The incidence of concomitant myxoma and fibroelastoma is exceptionally low, with fewer than five reported cases.
Implications:
- This case underscores the importance of thorough cardiac evaluation in patients with cryptogenic stroke, especially when multiple potential embolic sources are suspected.
- Intraoperative transesophageal echocardiography is invaluable for refining diagnoses and guiding surgical strategies in complex cardiac cases.
- The successful management involved addressing all identified cardiac abnormalities, preventing further embolic events.
Abstract:
We report a case in which multiple uncommon causes of an ischemic vascular accident coexisted in the same patient. The patient was admitted with signs of acute stroke. Investigation workup revealed a left atrial tumor (myxoma) and a patent foramen ovale. Intraoperatively, transesophageal echocardiography added new information: papillary fibroelastomas were found in the aortic valve. This finding dictated a change in the surgical plan, adding resection of aortic valve masses to the planned excision of the left atrial tumor and patent foramen ovale closure. The uniqueness of this case derives from the coexistence of rare primary cardiac tumors. There are only five cases in literature of myxoma concomitant with fibroelastoma and the occurrence of multiple fibroelastoma is also extremely rare. Moreover this case emphasizes the benefit of the intraoperative use of transesophageal echocardiography to improve the diagnosis and management of cardiac surgical patients.
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