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Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

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Related Experiment Video

Updated: May 13, 2026

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
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Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Published on: May 23, 2025

Lethal midline granuloma.

Varuna Mallya1, Avninder Singh, Manish Pahwa

  • 1Department of Pathology, National Institute of Pathology, ICMR, New Delhi, India.

Indian Dermatology Online Journal
|February 27, 2013
PubMed
Summary
This summary is machine-generated.

Lethal midline granuloma is a rare, destructive disease affecting the respiratory passages. Early diagnosis and intervention are crucial due to its grave nature and nonspecific symptoms.

Keywords:
Angiocentriclethal midline granulomalymphoma

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Last Updated: May 13, 2026

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Published on: May 31, 2017

Area of Science:

  • Medicine
  • Pathology
  • Otolaryngology

Background:

  • Lethal midline granuloma is a rare condition causing destructive lesions in the nasal and respiratory passages.
  • Nonspecific symptoms often lead to diagnostic delays, hindering timely treatment.
  • This condition requires urgent intervention due to its severity.

Observation:

  • A case report details a 35-year-old male with a two-month history of symptoms.
  • The patient presented with characteristic destructive and mutilating lesions.

Findings:

  • The case highlights the diagnostic challenges posed by nonspecific symptoms in lethal midline granuloma.
  • Delayed diagnosis can have detrimental consequences due to the aggressive nature of the disease.

Implications:

  • Emphasizes the need for heightened clinical suspicion for lethal midline granuloma.
  • Underscores the importance of prompt diagnosis and urgent intervention for improved patient outcomes.