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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Tardive dyskinesia with low dose amisulpride
1Consultant Psychiatrist, Schizophrenia Research Foundation, Chennai, Tamil Nadu, India.
Indian Journal of Psychiatry
|February 27, 2013
Summary
Low-dose amisulpride, used for depression, can cause dyskinesia. This study details a case of a depressed patient experiencing dyskinesia while on amisulpride and fluvoxamine.
Area of Science:
- Neuroscience
- Psychopharmacology
Background:
- Amisulpride is increasingly used for dysthymia and major depression.
- Low-dose amisulpride (50 mg) enhances dopamine release by blocking presynaptic auto-receptors, addressing dopaminergic hypoactivity in depression.
- Amisulpride is considered a primary treatment for dopaminergic transmission disorders in depression and schizophrenia.
Purpose of the Study:
- To report a case of dyskinesia in a patient treated with low-dose amisulpride and fluvoxamine for depression.
Main Methods:
- Case report detailing clinical observation and treatment of a depressed patient.
- Review of literature on amisulpride's mechanism of action and side effects.
Main Results:
- The patient developed dyskinesia while receiving low-dose amisulpride and fluvoxamine.
- This highlights a potential adverse effect of amisulpride, even at low doses, particularly when combined with other psychotropic medications.
Conclusions:
- Low-dose amisulpride, despite its dopaminergic benefits in depression, carries a risk of inducing dyskinesia.
- Concurrent use of fluvoxamine may influence the occurrence or severity of this adverse event.
- Further investigation into drug interactions and risk factors for amisulpride-induced movement disorders is warranted.
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