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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Related Experiment Video

Updated: May 13, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Progressive leg pain and weakness.

Digvijaya D Navalkele¹, Maria-Magdalena Georgescu, Dennis K Burns

¹Departments of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9036, USA.

|February 27, 2013

Summary

This summary is machine-generated.

A patient with prior cancer developed progressive leg weakness and pain. Despite initial steroid treatment, his condition worsened, leading to death, with elevated antibodies to varicella-zoster virus identified.

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Area of Science:

Neuroscience
Oncology
Infectious Disease

Background:

A 54-year-old male with a history of treated squamous cell carcinoma presented with neurological decline.
The patient experienced progressive, asymmetric leg pain and weakness over several months.

Observation:

Imaging revealed enhancement of the cauda equina and leptomeninges.
Cerebrospinal fluid analysis showed elevated protein, lymphocytic pleocytosis, and later, elevated IgG synthesis and varicella-zoster virus antibodies.
Initial treatment with intravenous steroids provided only temporary symptom relief.

Findings:

The case highlights a rare neurological complication potentially linked to varicella-zoster virus reactivation in an immunocompromised patient.
Despite negative initial cytology, the patient's progressive neurological deterioration and specific antibody titers suggested an underlying inflammatory or infectious process affecting the central nervous system.

Implications:

This case underscores the importance of considering opportunistic infections and inflammatory conditions in patients with a history of cancer presenting with unexplained neurological symptoms.
Early and comprehensive diagnostic evaluation, including serial cerebrospinal fluid analysis and specific antibody testing, is crucial for timely diagnosis and management of such complex neurological conditions.