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Related Concept Videos

Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Heterochromatin02:38

Heterochromatin

The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Euchromatin01:01

Euchromatin

The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...

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Wholemount In Situ Hybridization for Astyanax Embryos
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Published on: March 2, 2019

Ichthyosis hystrix.

Surajit Nayak1, Basanti Acharjya, Prasenjit Mohanty

  • 1Department of Skin and VD, MKCG Medical College and Hospital, Berhampur, Orissa, India.

Indian Dermatology Online Journal
|February 27, 2013
PubMed
Summary
This summary is machine-generated.

This report details a rare case of ichthyosis hystrix in a newborn, presenting as skin plaques and hair loss. The condition, an epidermal nevus, appeared without nail or skeletal issues.

Keywords:
Icthyosis hystrixepidermal nevus syndromeetretinate

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Last Updated: May 13, 2026

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Published on: December 28, 2018

Area of Science:

  • Dermatology
  • Medical Genetics

Background:

  • Epidermal nevi are congenital skin conditions.
  • Ichthyosis hystrix is a rare subtype characterized by thick, warty overgrowths.

Observation:

  • A three-day-old male infant presented with bilateral, linear, hyperpigmented, and hyperkeratotic verrucous plaques.
  • Patchy alopecia was observed on the scalp.

Findings:

  • The clinical presentation was suggestive of ichthyosis hystrix type of epidermal nevus.
  • No nail or skeletal abnormalities were detected.

Implications:

  • Highlights the importance of recognizing rare dermatological conditions in neonates.
  • Contributes to the understanding of epidermal nevus variations and ichthyosis hystrix.