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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

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Published on: March 17, 2019

Genetics of impulsive behaviour.

Laura Bevilacqua1, David Goldman

  • 1Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA. laura.bevilacqua@nyumc.org

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|February 27, 2013
PubMed
Summary
This summary is machine-generated.

This review explores impulsivity, a key trait in psychiatric disorders. Genetic research, including novel sequencing methods, is advancing our understanding of the biological underpinnings of impulsive behaviors.

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Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Psychiatry

Background:

  • Impulsivity is a complex trait linked to various psychiatric disorders.
  • Understanding its neurobiological basis is crucial for etiology and genetic studies.

Purpose of the Study:

  • To review the heritability of impulsivity constructs.
  • To discuss their potential as endophenotypes.
  • To explore genetic discovery strategies for impulsivity.

Main Methods:

  • Candidate gene approaches and re-sequencing.
  • Whole genome strategies for novel allele discovery.
  • Deep sequencing to identify specific genetic variants.

Main Results:

  • Functional genetic variants associated with impulsive behavior have been identified.
  • Deep sequencing revealed an uncommon HTR2B stop codon prevalent in a specific population.

Conclusions:

  • Genetic studies are vital for understanding impulsivity's etiology.
  • Novel sequencing methods facilitate the discovery of genes influencing impulsive behavior.
  • Findings have implications for both human and rodent models of impulsivity.