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Related Experiment Video

Updated: May 13, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Interventions for HIV-associated nephropathy.

Ismail Yahaya¹, Olalekan A Uthman, Muhammed Mubashir B Uthman

¹Save The Youth Initiative, Kaduna, Nigeria.illyahaya@yahoo.com.

The Cochrane Database of Systematic Reviews

|February 27, 2013

Summary

No randomized trials exist for human immunodeficiency virus-associated nephropathy (HIVAN) treatments. Observational data suggest steroids and ACE inhibitors may benefit kidney function in HIVAN patients, but more research is needed.

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Area of Science:

Nephrology
Infectious Diseases
Clinical Trials

Background:

Human immunodeficiency virus-associated nephropathy (HIVAN) is a leading cause of end-stage kidney disease (ESKD) in HIV-1 patients, particularly those of African descent.
Untreated HIVAN progresses rapidly to ESKD, necessitating interventions to reduce viral replication or slow kidney disease progression.
Current treatment approaches include antiretroviral therapy, ACE inhibitors, steroids, and cyclosporine, but their comparative effectiveness is unevaluated.

Purpose of the Study:

To assess the benefits and harms of adjunctive therapies for HIVAN management.
To evaluate the impact of these therapies on symptom severity and all-cause mortality.

Main Methods:

Searched multiple databases (Cochrane Renal Group, AEGIS, ClinicalTrials.gov, WHO ICTRP) and reference lists for relevant studies.
Included randomized controlled trials (RCTs) and quasi-RCTs of any therapy for HIVAN.
Data extraction involved independent screening, retrieval of full articles, and planned analysis of dichotomous (risk ratios) and continuous (mean difference) outcomes.

Main Results:

Identified four ongoing studies; none were completed RCTs or quasi-RCTs.
Two studies completed recruitment but await publication; one is ongoing, and one was suspended.
Observational data were summarized, but no formal analyses were conducted due to the lack of completed RCTs.

Conclusions:

There is a lack of RCT-based evidence to guide HIVAN treatment protocols.
Ongoing studies may provide future evidence, with three identified as potentially relevant.
Observational data suggest potential benefits of steroids and ACE inhibitors for kidney function in HIVAN, underscoring the need for high-quality RCTs.