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05:53

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Published on: July 6, 2013

Prevalence of cytomegalovirus infection in hospitalized infants

Ivan S Ivanov1, Nikolay I Popov, Rumyana I Moshe

  • 1Clinic of Children's and Genetic Diseases, Medical University, Plovdiv, Bulgaria. ivanovist@gmail.com

Folia Medica
|February 28, 2013
PubMed

Insights

Cytomegalovirus (CMV) infection is common in hospitalized infants, with prevalence increasing with age. Over half of infected infants under three months old show clear symptoms, highlighting the need for awareness and management of this viral infection.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Neonatal Health

Background:

  • Cytomegalovirus (CMV) infection data in hospitalized infants is limited and inconsistent.
  • Understanding CMV prevalence and clinical presentation in this population is crucial.

Purpose of the Study:

  • To determine the prevalence, clinical manifestations, risk factors, and predictive capacity of symptoms for CMV infection in hospitalized infants.
  • To investigate CMV infection rates in infants during their first year of life.

Main Methods:

  • Serological screening for CMV infection in 163 hospitalized infants over 10 months.
  • Follow-up of CMV IgG concentration in infants up to 6 months old and comparison with maternal levels.

Main Results:

  • Overall CMV prevalence was 33.1%, with higher rates in older infants (up to 71.9% in 7-12 month olds).
  • Clinically apparent CMV infection occurred in over half of infants up to 3 months old.
  • Hepatitis, cerebral vasculopathy, and pneumonia were identified as predictors of CMV infection.

Conclusions:

  • Hospitalized infants under one year old exhibit a high rate of CMV infections.
  • CMV infection contributes significantly to hospitalizations in newborns and young infants.
  • Early-onset CMV infection is often clinically apparent in infants.
Abstract

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