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[Do we know all effects of heparins in hemodialyzed patients?]

Milenka Sain1, Dragan Ljutić, Vedran Kovacić

  • 1Split University Hospital Center, Department of Nephrology and Dialysis, School of Medicine, University of Split, Split, Croatia. milenkas@net.hr

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti
|February 28, 2013
PubMed

Anticoagulation with heparins during hemodialysis (HD) is aimed at preventing the activation of coagulation in the extracorporeal circuit. As HD patients are exposed to unfractionated and low molecular weight heparins (LMWH) for years, non-hemorrhagic effects (osteoporosis, reduction of elevated blood pressure, with lesser intra- and interdialytic hypotensive episodes, effects on brain microvascular circulation and decreasing vascular dementia and Alzheimer's disease, and chronic and malignant diseases) require new trials with individualized doses of heparins.

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