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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Antiasthma Drugs: Muscarinic Receptor Antagonists01:20

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Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
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Updated: May 13, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Twenty-first century mast cell stabilizers.

D F Finn1, J J Walsh

  • 1School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland.

British Journal of Pharmacology
|February 28, 2013
PubMed
Summary
This summary is machine-generated.

New mast cell stabilizing drugs are being developed to improve upon existing treatments like disodium cromoglycate. Research explores natural products, synthetic compounds, and repurposed drugs for better allergy prevention.

Keywords:
allergyanti-IgEdisodium cromoglycateinhibitorsmast cellmediator releasenatural productssensitization

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Published on: July 4, 2018

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Last Updated: May 13, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Area of Science:

  • Pharmacology
  • Immunology
  • Drug Discovery

Background:

  • Mast cell stabilizing drugs prevent allergic reactions by inhibiting mediator release.
  • Disodium cromoglycate is effective but has limitations, necessitating novel agents.
  • There is a need for more affordable and convenient mast cell stabilizers.

Purpose of the Study:

  • To review current research on next-generation mast cell stabilizing drugs.
  • To evaluate diverse approaches including natural products, synthetic compounds, and repurposed drugs.
  • To suggest directions for preclinical evaluation of novel anti-allergic agents.

Main Methods:

  • Examination of substances from natural sources (phenols, alkaloids, terpenes, amino acids).
  • Investigation of synthetic inhibitors targeting signaling molecules like spleen tyrosine kinase (TK) and Janus kinase 3 (JAK3).
  • Evaluation of existing drugs, such as statins and nilotinib, for anti-allergic properties.

Main Results:

  • Natural products and synthetic derivatives show promise, though mechanisms are not always fully understood.
  • Inhibition of spleen TK and JAK3 are key targets in synthetic drug development.
  • Repurposed drugs like statins and nilotinib are being assessed for anti-allergic potential.

Conclusions:

  • Multiple avenues are being explored for developing improved mast cell stabilizers.
  • Further preclinical evaluation is crucial to realize the therapeutic potential of these novel agents.
  • The development of next-generation mast cell stabilizers aims for enhanced efficacy and patient convenience.