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Related Concept Videos

Aquaporins01:25

Aquaporins

Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.

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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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Aquaporin-4 expression in post-traumatic syringomyelia.

Sarah J Hemley1, Lynne E Bilston, Shaokoon Cheng

  • 1The Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia. sarah.hemley@mq.edu.au

Journal of Neurotrauma
|February 28, 2013
PubMed
Summary

Aquaporin-4 (AQP4) water channels are upregulated around syrinxes in a post-traumatic syringomyelia model. This suggests AQP4 may play a role in the fluid imbalance contributing to this condition.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Aquaporin-4 (AQP4) facilitates water transport in the central nervous system.
  • AQP4 is linked to fluid accumulation in conditions like spinal cord edema.
  • AQP4's role in post-traumatic syringomyelia is currently unknown.

Purpose of the Study:

  • To investigate AQP4 expression and distribution in an animal model of post-traumatic syringomyelia.
  • To explore the potential involvement of AQP4 in syrinx formation and enlargement.

Main Methods:

  • Utilized an excitotoxic amino acid/arachnoiditis rat model for post-traumatic syringomyelia.
  • Employed immunofluorescence and western blotting to analyze AQP4 and GFAP expression.
  • Examined tissue at various time-points post-surgery.

Main Results:

  • Increased AQP4 expression was observed at the syrinx level at 3 and 6 weeks post-surgery.
  • Elevated AQP4 levels were also found in the cervical cord rostral to the syrinx.
  • GFAP-positive astrocytes surrounded syrinx cavities, with overall GFAP expression decreasing over time.

Conclusions:

  • AQP4 expression is significantly altered in post-traumatic syringomyelia.
  • The localization of AQP4 around syrinx cavities suggests a role in fluid accumulation.
  • Further research is needed to determine if AQP4 alterations are causal or reactive to fluid changes.