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Receptor-based targeting of therapeutics
Neelesh Kumar Mehra1, Vijay Mishra, Narendra K Jain
1Department of Pharmaceutical Sciences, Dr HS Gour University, Sagar, India.
Therapeutic Delivery
|February 28, 2013
Summary
Targeted drug delivery using nanomedicines enhances cancer treatment efficacy. By engineering nanocarriers to bind specific cell receptors, this approach minimizes side effects and improves therapeutic outcomes.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Nanomedicines offer potential for improved drug delivery.
- Surface engineering of nanocarriers is crucial for targeted therapy.
- Specific receptors on cancer cells can be targeted for drug delivery.
Purpose of the Study:
- To review receptor-based targeting strategies for nanomedicines in cancer therapy.
- To discuss various receptors over-expressed on cancer cells.
- To explore different nanocarrier systems for targeted delivery.
Main Methods:
- Review of current literature on receptor-based drug targeting.
- Analysis of over-expressed receptors on cancer cells (e.g., transferrin, folate, integrin).
- Evaluation of various nanocarrier systems (nanoparticles, liposomes, dendrimers, etc.).
Main Results:
- Several receptors are over-expressed on cancer cells, enabling targeted delivery.
- Various nanocarrier systems can be engineered for receptor binding.
- Targeted delivery systems show promise in improving cancer treatment efficacy.
Conclusions:
- Receptor-based targeting of nanomedicines is a promising strategy for cancer management.
- This approach can enhance therapeutic efficacy and reduce drug-associated side effects.
- Further development of targeted nanomedicines is essential for effective cancer therapy.
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