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Behçet's disease in India: a dermatological perspective.
Archana Singal1, Namrata Chhabra, Deepika Pandhi
1Department of Dermatology and STD, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, India.
Indian Journal of Dermatology, Venereology and Leprology
|February 28, 2013
Summary
Behcet's disease in India primarily affects the skin and joints, presenting milder symptoms. Colchicine is an effective and safe treatment for these manifestations.
Area of Science:
- Rheumatology
- Dermatology
- Immunology
Background:
- Behcet's disease (BD) is a chronic, multi-system inflammatory disorder with high prevalence in Mediterranean populations.
- Clinical data on BD in India is scarce, with limited case series reported over the past two decades.
Purpose of the Study:
- To investigate the demographic characteristics, clinical features, and treatment outcomes of Behcet's disease patients in North India.
- To provide insights into the presentation and management of BD in an underrepresented population.
Main Methods:
- Prospective analysis of patients diagnosed with Behcet's disease between 1997 and 2011.
- Data collection included demographic profile, clinical manifestations, and treatment regimens.
Main Results:
- Twenty-nine patients were diagnosed with BD, showing a female preponderance (M:F = 1:3.8) and a mean age of onset of 27.4 years.
- Common manifestations included oral aphthae (100%), genital aphthae (93.1%), and articular involvement (68.9%).
- Colchicine was the primary treatment, proving effective and well-tolerated in all patients.
Conclusions:
- Behcet's disease in India appears to be a milder, primarily mucocutaneous and arthritic condition.
- Early diagnosis and management, particularly for mucocutaneous lesions, are crucial for preventing complications.
- Colchicine is recommended as a safe and effective therapeutic option for mucocutaneous and joint involvement in BD.
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