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Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: October 31, 2010
Non-AIDS-defining cancers in New Orleans
Marco Ruiz1, Daniel Johnson, Tom Reske
1Department of Medicine, Louisiana State Cancer Center Health Sciences Center, New Orleans, LA, USA. mruiz@lsuhsc.edu
Journal of the International Association of Providers of AIDS Care
|February 28, 2013
Summary
Non-AIDS-defining cancers, including lung, anal, and Hodgkin lymphoma, were frequently diagnosed at late stages in HIV-infected individuals in New Orleans. Further research is needed to clarify the role of HIV and other viruses in these malignancies.
Area of Science:
- Oncology
- Infectious Diseases
- Public Health
Background:
- The highly active antiretroviral therapy (HAART) era has seen an increase in non-AIDS-defining cancers among HIV-infected patients.
- A comprehensive review of non-AIDS-related malignancies in New Orleans was previously lacking.
Purpose of the Study:
- To conduct a retrospective review of non-AIDS-defining malignancies in HIV-infected patients in New Orleans.
- To analyze the types, stages, and patient demographics of these cancers.
Main Methods:
- Retrospective querying of institutional databases in New Orleans from 2001 to 2011.
- Utilized International Classification of Diseases, Ninth Revision (ICD-9) codes for HIV infection and cancer comorbidity identification.
Main Results:
- 16 cases of lung cancer (mean age 50), 20 of anal cancer (mean age 47), 14 of Hodgkin Lymphoma (mean age 42), and 5 of breast cancer (mean age 44) were identified.
- A high percentage of patients presented with advanced-stage cancers: lung (81%), anal (35%), Hodgkin Lymphoma (64%), and breast (40%).
Conclusions:
- The majority of non-AIDS-defining malignancies in this cohort were diagnosed at late stages, associated with worse outcomes and higher recurrence rates.
- Further investigation is required to elucidate the role of human immunodeficiency virus (HIV) and co-infections (e.g., Epstein-Barr virus, human papillomavirus) in oncogenesis.
- Clarification of potential mechanisms of oncogene activation in the context of HIV is needed.
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