Related Experiment Video

Updated: May 13, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Immunogenicity and reactogenicity of two diphtheria-tetanus-whole cell pertussis vaccines in Iranian pre-school

Saeed Zarei1, Mahmood Jeddi-Tehrani, Mohammad Mehdi Akhondi

  • 1Monoclonal Antibody Research Center; Avicenna Research Institute; Academic Center for Education, Culture, and Research (ACECR); Tehran, Iran; Reproductive Immunology Research Center; Avicenna Research Institute; ACECR; Tehran, Iran.

Human Vaccines & Immunotherapeutics
|February 28, 2013
PubMed

Insights

A study compared two diphtheria-tetanus-whole cell pertussis (DTwP) vaccines in Iranian children. The local DTwP vaccine showed lower immunogenicity against pertussis and more side effects than the commercial DTwP-Pasteur vaccine.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatrics

Background:

  • Diphtheria-tetanus-whole cell pertussis (DTwP) vaccines are crucial for preschool child immunization.
  • Evaluating local vaccine efficacy and safety against established commercial vaccines is essential for public health.

Purpose of the Study:

  • To compare the immunogenicity and reactogenicity of a local DTwP vaccine versus a commercial DTwP-Pasteur vaccine in Iranian preschool children.
  • To assess antibody responses to diphtheria, tetanus, and pertussis antigens.
  • To evaluate local and systemic adverse reactions following vaccination.

Main Methods:

  • A randomized, double-blind, multicenter prospective study involving 672 children aged 4-6 years.
  • Administration of either a local DTwP vaccine or DTwP-Pasteur vaccine according to the national immunization schedule.
  • Assessment of immunogenicity via ELISA and reactogenicity through parental diary cards for seven days post-vaccination.

Main Results:

  • No significant difference in immunogenicity against diphtheria and tetanus was observed between the two vaccines.
  • The local DTwP vaccine demonstrated significantly lower antibody titers against pertussis compared to DTwP-Pasteur (30.2 EU/ml vs. 47.9 EU/ml).
  • The local DTwP vaccine was associated with significantly higher frequencies of local and systemic reactions, including pain and fever.

Conclusions:

  • While immunogenicity for diphtheria and tetanus was comparable, the local DTwP vaccine was less effective against pertussis.
  • The local vaccine exhibited a higher reactogenicity profile, suggesting potential differences in bacterial strain, preparation, or formulation.
  • These findings highlight the need for further investigation into the local pertussis vaccine's components to improve efficacy and reduce adverse events.

Keywords:
Diphtheria-tetanus-pertussis vaccineenzyme-linked immunosorbent assayimmunogenicityrandomized controlled trialreactogenicityvaccination

More Related Videos

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells12:54

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...