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Updated: May 13, 2026

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
Published on: February 1, 2022
Microvascular obstruction complicating acute right ventricular myocardial infarction
Daniele Andreini1, Gianluca Pontone, Saima Mushtaq
1aCentro Cardiologico Monzino, IRCCS, Milan, Italy bRadiology Department - University Hospitals Leuven, Leuven, Belgium cFondazione C.N.R/Regione Toscana 'G. Monasterio', Pisa, Italy.
This case study highlights a myocardial infarction (MI) case with right ventricular involvement. Advanced imaging revealed persistent heart wall motion abnormalities and impaired function, with scar tissue evident on follow-up.
Area of Science:
- Cardiology
- Cardiovascular Imaging
Background:
- Inferior myocardial infarction (MI) can involve the right ventricle, impacting overall cardiac function.
- Percutaneous coronary intervention with stenting is a primary treatment for acute MI.
Observation:
- A patient with inferior MI and right ventricular involvement presented with left and right ventricular akinesia post-stenting.
- Cardiac magnetic resonance imaging demonstrated left ventricular inferior and inferolateral wall akinesia, and right ventricular inferior free wall akinesia.
- Late gadolinium enhancement (LGE) indicated myocardial infarction and microvascular obstruction (MVO) in both ventricles.
Findings:
- Persistent akinesia of the left ventricular inferior and inferolateral walls and right ventricular systolic dysfunction were noted at follow-up.
- Late gadolinium enhancement (LGE) persisted, signifying myocardial scarring.
- Resolution of microvascular obstruction (MVO) was observed, despite persistent wall motion abnormalities.
Implications:
- This case underscores the utility of cardiac MRI in assessing myocardial damage and microvascular integrity after MI.
- Understanding the extent and persistence of myocardial injury, including MVO, is crucial for prognosis and management.
- Right ventricular involvement in inferior MI can lead to persistent dysfunction, requiring careful monitoring.
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