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Related Concept Videos

Carrier Transport01:21

Carrier Transport

The generation of electrical current in semiconductors is fundamentally driven by two mechanisms: drift and diffusion. These processes are essential for the functionality and performance of semiconductor-based devices.
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The drift of charge carriers is started by an external electric field (E). Charged particles, such as electrons and holes, experience an acceleration between collisions with lattice atoms. For electrons, this results in a drift velocity (vd) given by:
Theory of Metallic Conduction01:17

Theory of Metallic Conduction

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Ion Channels01:19

Ion Channels

The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
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Facilitated Transport01:19

Facilitated Transport

The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a membrane via...
Facilitated Transport01:19

Facilitated Transport

The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a membrane via...
Diffusion01:12

Diffusion

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Related Experiment Video

Updated: May 13, 2026

Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence (TIRF) Microscopy
08:55

Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence (TIRF) Microscopy

Published on: February 17, 2023

Collective diffusion model for ion conduction through microscopic channels.

Yingting Liu1, Fangqiang Zhu

  • 1Department of Physics, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA.

Biophysical Journal
|February 28, 2013
PubMed
Summary
This summary is machine-generated.

We present a collective diffusion model to predict ion channel conductance from equilibrium simulations. This method accurately determines channel conductance without applying external voltage, simplifying analysis of ion transport.

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Measurement of Ion Concentration in the Unstirred Boundary Layer with Open Patch-Clamp Pipette: Implications in Control of Ion Channels by Fluid Flow
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Measurement of Ion Concentration in the Unstirred Boundary Layer with Open Patch-Clamp Pipette: Implications in Control of Ion Channels by Fluid Flow

Published on: January 7, 2019

Recapitulation of an Ion Channel IV Curve Using Frequency Components
10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

Related Experiment Videos

Last Updated: May 13, 2026

Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence (TIRF) Microscopy
08:55

Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence (TIRF) Microscopy

Published on: February 17, 2023

Measurement of Ion Concentration in the Unstirred Boundary Layer with Open Patch-Clamp Pipette: Implications in Control of Ion Channels by Fluid Flow
05:42

Measurement of Ion Concentration in the Unstirred Boundary Layer with Open Patch-Clamp Pipette: Implications in Control of Ion Channels by Fluid Flow

Published on: January 7, 2019

Recapitulation of an Ion Channel IV Curve Using Frequency Components
10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

Area of Science:

  • * Biophysics and Nanotechnology
  • * Physical Chemistry

Background:

  • * Ion conduction through microscopic channels is crucial in biological systems and nanotechnology.
  • * Understanding the current-voltage (I-V) dependence of ion channels is essential for predicting ion transport behavior.

Purpose of the Study:

  • * To develop and validate a collective diffusion model for ion channels.
  • * To quantitatively link equilibrium ion permeation to voltage-driven ionic fluxes.
  • * To determine channel conductance from equilibrium simulations without applied voltage.

Main Methods:

  • * Development of a collective diffusion model for ion transport.
  • * Validation using molecular-dynamics simulations of a conical nanopore and an α-hemolysin channel.
  • * Simulation under both equilibrium and non-equilibrium conditions.

Main Results:

  • * The collective diffusion model effectively captures coupled cation and anion motions.
  • * Channel conductance predicted from equilibrium simulations aligns with results from non-equilibrium simulations.
  • * Ionic current rectification is primarily influenced by channel charges, not geometric asymmetry.

Conclusions:

  • * The collective diffusion model provides a robust method for calculating ion channel conductance.
  • * Equilibrium simulations can predict channel behavior under applied voltage, simplifying experimental and computational efforts.
  • * Channel charge distribution is a key factor in ion channel rectification properties.