Related Experiment Video

Updated: May 13, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

MicroRNAs: a new piece in the paediatric cardiovascular disease puzzle

Ahmed Omran1, Dalia Elimam, Keith A Webster

  • 1Department of Pediatrics and Neonatology, Suez Canal University, Ismailia, Egypt.

Cardiology in the Young
|February 28, 2013
PubMed

Insights

MicroRNAs (miRs) play a key role in pediatric cardiovascular diseases. Understanding these miRs is vital for developing new treatments and prevention strategies for children's heart conditions.

Area of Science:

  • Pediatric Cardiology
  • Molecular Biology
  • Genetics

Background:

  • Cardiovascular diseases represent a significant public health concern in children.
  • MicroRNAs (miRs) are increasingly recognized for their involvement in cardiac development, function, and disease.
  • Current understanding of miR roles in pediatric cardiovascular conditions is limited.

Purpose of the Study:

  • To review the current literature on the role of microRNAs (miRs) in pediatric cardiovascular diseases.
  • To highlight the importance of miR-based research for understanding disease pathogenesis.
  • To encourage further investigation into novel preventive and therapeutic strategies targeting miRs in pediatric cardiology.

Main Methods:

  • Comprehensive literature review of studies investigating microRNAs in pediatric cardiovascular disorders.
  • Analysis of existing research on miR involvement in heart development and function.
  • Synthesis of findings related to specific pediatric cardiovascular conditions and their associated miRs.

Main Results:

  • MicroRNAs are implicated in various aspects of pediatric heart development and disease.
  • Specific miRs have been identified as potential biomarkers and therapeutic targets in conditions like congenital heart defects and cardiomyopathies.
  • Further research is needed to fully elucidate the complex roles of miRs.

Conclusions:

  • MicroRNA research offers promising avenues for improving diagnosis, treatment, and prevention of pediatric cardiovascular diseases.
  • Targeting miRs could lead to enhanced cardiac development and improved clinical outcomes for affected children.
  • Continued investigation into miR-based therapies is crucial for reducing morbidity and mortality in pediatric cardiology.

More Related Videos

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...