Related Experiment Video
Updated: May 13, 2026
08:34
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Proton beam therapy for malignancy in Bloom syndrome
M Mizumoto1, H Hashii, M Senarita
1Department of Radiation Oncology, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, Japan. mizumoto@pmrc.tsukuba.ac.jp
Summary
Proton beam therapy (PBT) was used for oropharyngeal cancer in a patient with Bloom syndrome, a DNA repair disorder. PBT showed excellent dose concentration, achieving a tumor response despite treatment interruptions due to mucositis.
Area of Science:
- Oncology
- Radiation Oncology
- Genetics
Background:
- Bloom syndrome is a rare genetic disorder characterized by genomic instability and increased sensitivity to DNA damage, including radiotherapy.
- Patients with Bloom syndrome often present challenges in cancer treatment due to their radiosensitivity.
More Related Videos
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...