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Relationship between uric acid and vascular structure and function in hypertensive patients and sex-related

Manuel A Gómez-Marcos1, Jose I Recio-Rodríguez, María C Patino-Alonso

  • 1Primary Care Research Unit, Alamedilla Health Center, Salamanca, Spain. magomez@usal.es

American Journal of Hypertension
|February 28, 2013
PubMed

Insights

Uric acid (UA) is linked to vascular changes in hypertensive individuals. Associations differ by sex, with UA correlating with pulse-wave velocity (PWV) in women and ambulatory arterial stiffness index (AASI) in both sexes.

Area of Science:

  • Cardiovascular Research
  • Hypertension Studies
  • Vascular Biology

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Uric acid (UA) is increasingly recognized as a potential contributor to vascular damage.
  • Understanding the relationship between UA and vascular parameters is crucial for risk stratification.

Purpose of the Study:

  • To analyze the relationship between uric acid (UA) and vascular structure and function.
  • To assess vascular parameters including carotid intima-media thickness, pulse-wave velocity (PWV), central arterial pressure, and augmentation index.
  • To evaluate sex-related differences in these associations.

Main Methods:

  • Cross-sectional study of 366 hypertensive individuals (aged 34-75 years).
  • Vascular structure assessed by carotid intima-media thickness.
  • Arterial stiffness evaluated by PWV; vascular function by augmentation index and ambulatory arterial stiffness index (AASI).

Main Results:

  • In women, UA positively correlated with PWV and AASI.
  • In global analysis, UA negatively correlated with central/peripheral augmentation indices and positively with carotid intima-media thickness.
  • Multiple regression showed UA associated with PWV in women, and AASI differently in men and women.

Conclusions:

  • Serum UA correlates with vascular structure (intima-media thickness) and stiffness (PWV).
  • Associations with augmentation indices were observed but lost after adjustment.
  • Ambulatory arterial stiffness index (AASI) showed sex-specific associations with UA.
Abstract

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